Chilblain-like lesions after BNT162b2 mRNA COVID-19 vaccine: a case report suggesting that 'COVID toes' are due to the immune reaction to SARS-CoV-2

Article Pathology

Spectrum of Clinicopathologic Findings in COVID-19-induced Skin Lesions Demonstration of Direct Viral Infection of the Endothelial Cells

Maria C. Garrido Ruiz et al.

Summary: This study focuses on the skin lesions caused by COVID-19, identifying different types of skin manifestations with chilblain-like lesions being the most common. While these skin symptoms may not be directly correlated with disease severity, they can assist in early recognition and control of infection in some cases.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2021)

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Article Dermatology

Clinical, Laboratory, and Interferon-Alpha Response Characteristics of Patients With Chilblain-like Lesions During the COVID-19 Pandemic

Thomas Hubiche et al.

Summary: In a series of 40 patients with chilblain-like lesions during the COVID-19 pandemic, none had positive PCR tests, while 30% had positive COVID-19 serologic results. These patients showed type I interferonopathy patterns and histologic features, with significant interferon-alpha responses.

JAMA DERMATOLOGY (2021)

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Editorial Material Public, Environmental & Occupational Health

'Blue toes' following vaccination with the Pfizer BNT162b2 mRNA COVID-19 vaccine

Benjamin Davido et al.

JOURNAL OF TRAVEL MEDICINE (2021)

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Letter Medicine, General & Internal

Delayed Large Local Reactions to mRNA-1273 Vaccine against SARS-CoV-2

Kimberly G. Blumenthal et al.

Summary: Twelve patients developed delayed cutaneous reactions days after initial injection-related symptoms resolved. These reactions, some as severe as grade 3, were resolved in a few days with local therapy. After receiving the second vaccination, 6 patients had no recurrence of the local reaction, 3 had similar reactions to the initial injection reaction, and 3 had milder reactions.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Letter Dermatology