Communication-The Role of Ascorbic Acid Oxidation During Neural Stimulation

During neural stimulation it is important to ensure charge transfer does not cause tissue damage. The safe range for stimulation is often defined by the oxidation/reduction of water. However, many biological molecules, such as ascorbic acid (AA), have lower oxidation potentials than water. Due to its low oxidation potential and high concentrations in the brain, we examined the role of AA oxidation during neural stimulation. By measuring the voltage transients during current-controlled stimulation we show significant AA oxidation occurs at stimulation levels typically deemed safe. These results highlight the importance of considering the effect of electrical stimulation on biological molecules.

Automated summary

During neural stimulation, it is important to consider the impact of electrical stimulation on biological molecules, especially those with low oxidation potentials like ascorbic acid (AA). Research findings indicate that significant AA oxidation occurs even at stimulation levels typically deemed safe.