Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 143, Issue 35, Pages 14046-14052Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.1c05092
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Funding
- College of Chemistry and Molecular Engineering, Peking University
- National Science Foundation of China [31521004, 21673011, 21822101, 21977002]
- National Key Research and Development Program of China [2017YFA0104003]
- Li Ge-Zhao Ning Life Science Junior Research Fellowship
- Beijing Outstanding Young Scientist Program [BJJWZYJH01201910001001]
- PKUAIC
- High-Performance Computing Platform of Peking University
- Beijing National Laboratory for Molecular Sciences, Peking-Tsinghua Center for Life Sciences, Shenzhen Bay Laboratory
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A new and general method has been developed to functionalize the C(sp(3))-C(sp(2)) bond of alkyl and alkene linkages, allowing for the generation of carbon-centered radicals that can undergo cross-coupling reactions. This one-pot protocol utilizes easily accessible alkene feedstocks for organic synthesis, showing excellent compatibility with various functional groups and eliminating the need for a photoredox catalyst.
A new and general method to functionalize the C(sp(3))-C(sp(2)) bond of alkyl and alkene linkages has been developed, leading to the dealkenylative generation of carbon-centered radicals that can be intercepted to undergo Ni-catalyzed C(sp(3))-C(sp(2)) cross-coupling. This one-pot protocol leverages the easily procured alkene feedstocks for organic synthesis with excellent functional group compatibility without the need for a photoredox catalyst.
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