4.8 Article

Low-Valent Tungsten Catalysis Enables Site-Selective Isomerization-Hydroboration of Unactivated Alkenes

Journal

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume 143, Issue 37, Pages 14981-14986

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jacs.1c07162

Keywords

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Funding

  1. ICIQ
  2. FEDER/MICIU [AEI/PGC2018-096839-B100]
  3. MCI/AIE [CEX2019-000925-S]
  4. La Caixa
  5. NIH [5R35GM125052-04]
  6. Lindemann Trust
  7. English-Speaking Union

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This tungsten-catalyzed hydroboration of unactivated alkenes at distal C(sp(3))-H bonds with the aid of native directing groups is characterized by simplicity, exquisite regio- and chemoselectivity, and wide substrate scope, providing a complementary site-selectivity pattern to other metal-catalyzed borylation reactions and chain-walking protocols.
A tungsten-catalyzed hydroboration of unactivated alkenes at distal C(sp(3))-H bonds aided by native directing groups is described herein. The method is characterized by its simplicity, exquisite regio- and chemoselectivity, and wide substrate scope, offering a complementary site-selectivity pattern to other metal-catalyzed borylation reactions and chain-walking protocols.

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