Journal
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
Volume 30, Issue 9, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jstrokecerebrovasdis.2021.105938
Keywords
COVID-19; Vaccine; Vaccine-induced; Immune Thrombotic Thrombocytopenia; Cerebral Venous Sinus Thrombosis; Disseminated Intravascular Coagulation; Death
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COVID-19 is not only a respiratory disease but also involves complications in other organs, necessitating the urgent development of effective vaccines to control its global spread.
Coronavirus is a novel human pathogen causing fulminant respiratory syndrome (COVID-19). Although COVID-19 is primarily a disease of the lungs with florid respira-tory manifestations, there are increasing reports of cardiovascular, musculoskeletal, gas-trointestinal, and thromboembolic complications. Developing an effective and reliable vaccine was emergently pursued to control the catastrophic spread of the global pan-demic. We report a fatal case of vaccine-induced immune thrombotic thrombocytopenia (VITT) after receiving the first dose of the ChAdOx1 nCoV-19 vaccine. We attribute this fatal thrombotic condition to the vaccine due to the remarkable temporal relationship. The proposed mechanism of VITT is production of rogue antibodies against platelet fac-tor-4 resulting in massive platelet aggregation. Healthcare providers should be aware of the possibility of such fatal complication, and the vaccine recipients should be warned about the symptoms of VITT.
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