Characteristics and Bioactivities of Carrageenan/Chitosan Microparticles Loading α-Mangostin

This study attempted to develop carrageenan/chitosan based microparticles loading alpha-mangostin which was extracted from Vietnamese mangosteen skin. The carrageenan/chitosan/alpha-mangostin microparticles were prepared by ionic gelation method by mixing chitosan, carrageenan with alpha-mangostin and subsequently cross-linking the mixtures with sodium tripolyphosphate crosslinking agent. The content of alpha-mangostin in microparticles was changed to evaluate the effect of alpha-mangostin content on physical, morphological properties, particles size and bioactivities of the carrageenan/chitosan/alpha-mangostin microparticles. The obtained results showed that carrageenan, chitosan was interacted together and with alpha-mangostin. The presence of polymers matrix improved the release ability of alpha-mangostin into ethanol/pH buffer solutions. The carrageenan/chitosan/alpha-mangostin microparticles have antibacterial (gram (+) strains) and antioxidant activities. The results suggested that combination of chitosan and carrageenan in the microparticles can enhance the control release of alpha-mangostin into solutions as well as keep the bioactivities and reduce the vero cell toxicity of alpha-mangostin.

Automated summary

The study developed microparticles loaded with alpha-mangostin extracted from Vietnamese mangosteen skin using carrageenan and chitosan. The microparticles exhibited improved release ability of alpha-mangostin into solutions, maintained its bioactivities, reduced vero cell toxicity, and showed antibacterial and antioxidant activities. The combination of chitosan and carrageenan in the microparticles enhanced the controlled release of alpha-mangostin.