4.5 Article

Advances in the Structural Design of Polyelectrolyte Complex Micelles

Journal

JOURNAL OF PHYSICAL CHEMISTRY B
Volume 125, Issue 26, Pages 7076-7089

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.jpcb.1c01258

Keywords

-

Funding

  1. U.S. Department of Commerce, National Institute of Standards and Technology (NIST), Center for Hierarchical Materials Design (CHiMaD) [70NANB19H005]
  2. NIST-CHiMaD Postdoctoral Fellowship

Ask authors/readers for more resources

PCMs are unique self-assembled nanoparticles with great potential for delivery and fundamental polymer physics research. Controlled block copolymer design allows precise tuning of size, morphology, and stability of PCMs for tailored nanocarriers. Recent advances focus on predictive PCM design and dynamics characterization using time-resolved scattering techniques.
Polyelectrolyte complex micelles (PCMs) are a unique class of self-assembled nanoparticles that form with a core of associated polycations and polyanions, microphase-separated from neutral, hydrophilic coronas in aqueous solution. The hydrated nature and structural and chemical versatility make PCMs an attractive system for delivery and for fundamental polymer physics research. By leveraging block copolymer design with controlled self-assembly, fundamental structure-property relationships can be established to tune the size, morphology, and stability of PCMs precisely in pursuit of tailored nanocarriers, ultimately offering storage, protection, transport, and delivery of active ingredients. This perspective highlights recent advances in predictive PCM design, focusing on (i) structure-property relationships to target specific nanoscale dimensions and shapes and (ii) characterization of PCM dynamics primarily using time-resolved scattering techniques. We present several vignettes from these two emerging areas of PCM research and discuss key opportunities for PCM design to advance precision medicine.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available