Journal
JOURNAL OF PERIODONTOLOGY
Volume 93, Issue 2, Pages 298-307Publisher
WILEY
DOI: 10.1002/JPER.20-0887
Keywords
analgesia; ibuprofen; nimesulide; pain; pain management; postoperative; preanesthetic medication
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Funding
- National Council for Scientific and Technological Development (CNPq-Brasilia, Brazil)
- Coordination for the Improvement of Higher Education Personnel (CAPES-Brasilia, Brazil)
- Research Support Foundation of the State of Minas Gerais (FAPEMIG-Belo Horizonte, Brazil)
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This study evaluated and compared the analgesic effects of preemptive administration of ibuprofen and nimesulide in open flap periodontal surgeries. The results showed that nimesulide had better pain control effects at 24, 48, and 72 postoperative hours, indicating a higher overall preemptive effect.
Background Data on preemptive analgesia in periodontal surgeries are scarce and still diverse. The aim of this study was to evaluate and compare the analgesic effects of the preemptive administration of ibuprofen and nimesulide in open flap periodontal surgeries. Methods The present randomized controlled clinical trial comprised 40 individuals, divided into two groups (n = 20), according to the test drug (ibuprofen and nimesulide) to be administered 1 hour preoperatively. Participants underwent bilateral periodontal surgeries at two different times, and were randomly given the test drug or placebo in a split-mouth design. Postoperative pain and rescue medication were evaluated at different times. Comparisons between ibuprofen and nimesulide were performed through a Generalized Estimation Equation model, using test drug and evaluation times, along with an interaction between these two variables as predictors. Results In intergroup comparisons regarding pain control, ibuprofen showed better effects than placebo only at the first postoperative hour, whereas nimesulide showed better effects than placebo at 1, 6, 24, and 48 postoperative hours. In intergroup comparisons, nimesulide showed better effects than ibuprofen at 24, 48, and 72 postoperative hours, demonstrating a higher overall preemptive effect. No differences were observed in relation to the number of rescue medication. Conclusion Preemptive administration of nimesulide showed better overall preemptive effects on postoperative pain control when compared with ibuprofen.
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