Journal
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
Volume 46, Issue 3, Pages 618-625Publisher
WILEY
DOI: 10.1002/jpen.2138
Keywords
alkaline phosphatase; ethnicity; fractures; health outcomes; linear growth velocity; neonatal intensive care unit; phosphorus; race; socioeconomic factors; very low-birth-weight infants; very preterm infants; vitamin D deficiency; vitamin D supplementation
Categories
Ask authors/readers for more resources
The study found a significant association between maternal age, gestational age, infant birth weight, and race/ethnicity with the receipt of adjusted vitamin D dose for VLBW and very preterm infants, but no significant associations were found between health indicators and vitamin D dose.
Background In 2017, the neonatal intensive care unit (NICU) at Rush University Medical Center (RUMC) implemented a protocol to provide individualized vitamin D supplementation dosing for very low-birth-weight (VLBW) and very preterm infants. This study evaluated the association of demographic and socioeconomic factors, vitamin D dose, and health indicators, including bone mineral status, measured by alkaline phosphatase and phosphorus levels; linear growth velocity; and occurrence of fractures. Method This retrospective cross-sectional study included 227 VLBW or very preterm infants (34 VLBW, 12 very preterm, and 181 VLBW and very preterm) born in and discharged from the RUMC NICU between February 1, 2017, and October 31, 2019. Vitamin D dose was classified as adjusted (supplemental dose of 800 IU/day, n = 169) or standard (recommended dose of 400 IU/day, n = 58), per the protocol. Binary logistic and linear regression models were constructed to test the associations between infant and maternal characteristics and vitamin D dose group and between vitamin D dose group and health indicators. Results The analysis found a statistically significant association between maternal age, gestational age, infant birth weight, and race/ethnicity and receipt of an adjusted vitamin D dose. No significant associations were found between health indicators and vitamin D dose. Conclusion Sociodemographic factors may influence vitamin D deficiency in VLBW and very preterm infants in the NICU. At this time, there is insufficient evidence to support a tailored approach, but further research in this area is warranted.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available