Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 86, Issue 13, Pages 8576-8589Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c00195
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Funding
- DST-SERB Early Career Award
- DST-SERB [ECR/2015/000253]
- DBT [BT/PRI1450/BRB/I0/1370/2015]
- UGC
- CSIR
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A new chemical methodology has been developed for the rapid synthesis of diverse semi-synthetic protein families, including various types of proteins with great potential for applications.
The design of well-defined monodispersed selfassembling semi-synthetic proteins is emerging as a promising research avenue. These proteins hold great potential to be used as scaffolds for various protein nanotechnology applications. Currently, there are very few chemical methods reported; however, they suffer from elaborate multistep organic synthesis. Herein, we report a new chemical methodology for the rapid synthesis of a diverse set of semi-synthetic protein families, which include protein amphiphiles, facially amphiphilic protein-dendron conjugates, and pH-sensitive protein-dendron conjugates. This chemical method holds great potential to access a wide variety of semi-synthetic proteins in a short time.
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