4.7 Article

Direct Electrochemical Selenylation/Cyclization of Alkenes: Access to Functionalized Benzheterocycles

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 86, Issue 22, Pages 16045-16058

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c01267

Keywords

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Funding

  1. National Natural Science Foundation of China [21901052]
  2. Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme
  3. Guangdong Basic and Applied Basic Research Foundation [2020A1515010722]

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This study introduced a catalyst-free, environmentally friendly, and efficient electrochemical selenylation/cyclization method for the synthesis of diverse functionalized benzheterocycles. The process proceeded smoothly and could be scaled up to gram quantity with convenient operation in an undivided cell.
A catalyst-free, environmentally friendly, and efficient electrochemical selenylation/cyclization of alkenes has been developed with moderate to excellent yields. This selenylated transformation proceeds smoothly and tolerates a wide range of synthetically useful groups to deliver diverse functionalized benzheterocycles, including iminoisobenzofuran, lactones, oxindoles, and quinolinones. Moreover, the present synthetic route could also be readily scaled up to gram quantity with convenient operation in an undivided cell.

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