Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 86, Issue 12, Pages 8479-8488Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c00472
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Funding
- NIH [R35CA197589, F31CA232477, 5T32GM067543]
- American Cancer Research Professorship
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A novel and facile two-step synthesis method for 3,4-unsubstituted isoquinolin-1(2H)-ones is described, involving a Suzuki cross-coupling reaction and platinum-catalyzed nitrile hydrolysis and cyclization.
A novel, facile, and expeditious two-step synthesis of 3,4-unsubstituted isoquinolin-1(2H)-ones from a Suzuki cross-coupling between 2-halobenzonitriles and commercially available vinyl boronates followed by platinum-catalyzed nitrile hydrolysis and cyclization is described.
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