Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 86, Issue 18, Pages 12705-12713Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c01220
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Funding
- Alexander von Humboldt foundation for the Linkage research Group Program
- National Institute for Medical Research Development (NIMAD) [995788]
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Practical Pd-catalyzed 2-pyridones were designed to synthesize chromeno[2,3-b]pyridine-2-ones through domino nucleophilic addition and decarboxylative arylation. This methodology offers an efficient approach to construct bioactive fused-heterocyclic skeletons in a single step with high selectivity and good yields.
Practical Pd-catalyzed 2-pyridones were designed to achieve chromeno[2,3-b]pyridine-2-ones. The reaction proceeds through domino nucleophilic addition and decarboxylative arylation, respectively. This methodology offers a moderately efficient approach to construct the bioactive, fused-heterocyclic skeletons via selective C-O bond formation and decarboxylative arylation in a single step with high selectivity and good yields.
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