4.7 Article

Electro-Oxidative C-N Bond Formation through Azolation of Indole Derivatives: An Access to 3-Substituent-2-(Azol-1-yl)indoles

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 86, Issue 22, Pages 16059-16067

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c01271

Keywords

-

Funding

  1. National Natural Science Foundation of China [21602078]
  2. Pearl River Talent Program of Guangdong Province (Youth Top-Notch Talent) [2017GC010302]
  3. Guangdong Basic and Applied Basic Research Foundation [2019A1515011743]
  4. Jinan University

Ask authors/readers for more resources

A practical protocol for synthesizing 3-substituent-2-(azol-1-yl)indole derivatives has been developed through an electrochemical oxidative cross coupling process. This strategy tolerates a variety of functional groups and is suitable for gram scale synthesis, as well as late-stage functionalization of bioactive molecules.
A practical protocol to synthesize 3-substituent-2-(azol-1-yl)indole derivatives has been developed via an electrochemical oxidative cross coupling process under mild conditions. This electro-oxidative C-N bond formation strategy tolerates a range of functional groups and is amenable to gram scale synthesis. Moreover, this method was applied to the late-stage functionalization of bioactive molecules.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available