Visible-Light-Driven, Palladium-Catalyzed Heck Reaction of Internal Vinyl Bromides with Styrenes

Functionalized 1,3-dienes were efficiently accessed from visible-light-driven, palladium-catalyzed Heck reaction of S,S-functionalized internal vinyl bromides with styrenes under mild conditions. This Heck reaction showcased tolerance of a wide array of functional groups, afforded the target products in moderate to excellent yields through a radical reaction pathway. The resultant diene products could be further transformed to highly functionalized trisubstituted furan derivatives.

Automated summary

Functionalized 1,3-dienes were efficiently accessed through palladium-catalyzed Heck reaction under mild conditions, showcasing tolerance of various functional groups and further transformation potential to highly functionalized trisubstituted furan derivatives.