4.7 Article

Ru(II)-Catalyzed Asymmetric Transfer Hydrogenation of 3-Fluorochromanone Derivatives to Access Enantioenriched cis-3-Fluorochroman-4-ols through Dynamic Kinetic Resolution

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 86, Issue 17, Pages 12054-12063

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c01415

Keywords

-

Funding

  1. Ministere de l'Enseignement Superieur de la Recherche et de l'Innovation (MESRI)
  2. Centre National de la Recherche Scientifique (CNRS)
  3. Chamoreau (Sorbonne Universite, Paris)

Ask authors/readers for more resources

Enantioenriched cis-3-fluoro-chroman-4-ol derivatives were conveniently prepared through ruthenium-catalyzed asymmetric transfer hydrogenation using a dynamic kinetic resolution process. The reaction proceeded under mild conditions, affording the reduced fluorinated alcohols in good yields, high diastereomeric ratios, and excellent enantioselectivities.
Enantioenriched cis-3-fluoro-chroman-4-ol derivatives were conveniently prepared by the ruthenium-catalyzed asymmetric transfer hydrogenation of a new family of 3-fluoro-chromanones through a dynamic kinetic resolution process. The reaction proceeded under mild conditions using a low catalyst loading and HCO2H/Et3N (1:1) as the hydrogen source, affording the reduced fluorinated alcohols in good yields (80-96%), high diastereomeric ratios (up to 99:1 dr), and excellent enantioselectivities (up to >99% ee).

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available