Journal
JOURNAL OF NUCLEAR MEDICINE
Volume 62, Issue 12, Pages 1677-1683Publisher
SOC NUCLEAR MEDICINE INC
DOI: 10.2967/jnumed.121.262009
Keywords
breast cancer; axillary lymph node metastasis; PET/MRI; oncologic imaging
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This study aimed to compare different imaging modalities for detecting axillary lymph node metastases in women with newly diagnosed breast cancer. The results show that F-18-FDG PET/MRI had the highest accuracy in determining axillary lymph node status, while axillary sonography had the highest specificity. In a clinical setting, combining F-18-FDG PET/MRI and axillary sonography may offer even greater diagnostic accuracy.
The purpose of this study was to compare breast MRI, thoracic MRI, thoracic F-18-FDG PET/MRI, and axillary sonography for the detection of axillary lymph node metastases in women with newly diagnosed breast cancer. Methods: This prospective double-center study included patients with newly diagnosed breast cancer between March 2018 and December 2019. Patients underwent thoracic (F-18-FDG PET/)MRI, axillary sonography, and dedicated prone breast MRI. Datasets were evaluated separately regarding nodal status (nodal-positive vs. nodal-negative). Histopathology served as the reference standard in all patients. The diagnostic performance of breast MRI, thoracic MRI, thoracic PET/MRI, and axillary sonography in detecting nodal-positive patients was tested by creating receiver-operating-characteristic curves (ROC) with a calculated area under the curve (AUC). Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were calculated for all 4 modalities. A McNemar test was used to assess differences. Results: In total, 112 female patients (mean age, 53.04 +/- 12.6 y) were evaluated. Thoracic PET/MRI showed the highest AUC, with a value of 0.892. The AUCs for breast MRI, thoracic MRI, and sonography were 0.782, 0.814, and 0.834, respectively. Differences between thoracic PET/MRI and axillary sonography, thoracic MRI, and breast M Rlwere statistically significant (PET/MRI vs. axillary sonography, P = 0.01; PET/MRI vs. thoracic MRI, P = 0.02; PET/MRI vs. breast MRI, P = 0.03). PET/MRI showed the highest sensitivity (81.8% [36/44]; 95% CI, 67.29%-91.81%), whereas axillary sonography had the highest specificity (98.5% [65/66]; 95% CI, 91.84%-99.96%). Conclusion: F-18-FDG PET/MRI outperforms axillary sonography, breast MRI, and thoracic MRI in determining the axillary lymph node status. In a clinical setting, the combination of F-18-FDG PET/MRI and axillary sonography might be considered to provide even greater accuracy in diagnosis.
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