Journal
JOURNAL OF NON-CRYSTALLINE SOLIDS
Volume 561, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jnoncrysol.2021.120755
Keywords
Bioactive glass; biocompatibility; biosilica; bone support; composite putty; sodium alginate
Funding
- Yildiz Technical University Scientific Research Projects Coordination Unit [FBA-2017-3106]
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This study compared the rheological features, bioactivity behavior, and effect on cell viability of composite putties containing biosilica and commercial silica based bioactive glasses. The results showed differences between the two types of materials in rheological and bioactivity properties, but both did not have adverse effects on cell viability.
In this study, we prepared biosilica and commercial silica based bioactive glasses with melt-quenching method, and utilized them as the solid phase of composite putties produced using sodium alginate polymer as the liquid phase. Biosilica based and commercial silica based bioactive glass containing composite putties were investigated and compared in terms of rheological features, bioactivity behavior and effect on cell viability. Rheological studies revealed that produced composite putties using both biosilica based and commercial silica based bioactive glasses were both shear thinning (pseudo-plastic) fluids with different consistency coefficient values. Biosilica based and commercial silica based composite putty materials showed differences between each other in terms of bioactivity and did not show any adverse effect on cell viability. Thus, the material features of meltquenched biosilica based bioactive glass/alginate formulations seem relevant for bone tissue engineering applications and biosilica may reduce production costs of these materials.
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