Combination of Na-Ca-phosphate and fluorapatite in wollastonite-diopside glass-ceramic: degradation and biocompatibility

The effect of introducing Na-Ca-phosphate (NCP) and/or fluorapatite in the bioactive wollastonite-diopside (WD) was investigated in this study. The prepared materials were characterized by DTA, XRD, and SEM/EDX. Moreover, the density and Vicker's microhardness were measured. The in vitro bioactivity test was carried out in SBF, and the cell viability test was evaluated using the Vero cells. The results showed that NCP-containing WD glassceramic was showed the lowest density value due to its low densification, and accordingly, it showed the lowest Vicker`s microhardness value. Furthermore, combining Na-Ca-phosphate in WD was increased the cell viability better than that included fluorapatite, whereas, the combination of both crystalline phases led to increase the cytotoxicity to the highest value. In conclusion, different properties of wollastonite-diopside glass-ceramics can be tailored. Hence, these glass-ceramics are expected to be useful materials in promising biomedical applications, such as orthopedics and dentistry.

Automated summary

This study investigated the effect of introducing Na-Ca-phosphate and/or fluorapatite in bioactive wollastonite-diopside. The results showed that NCP-containing WD glassceramic had the lowest density and microhardness values, while the combination of Na-Ca-phosphate and fluorapatite led to increased cytotoxicity. The properties of WD glass-ceramics can be tailored for biomedical applications.