Journal
JOURNAL OF NEUROSCIENCE
Volume 41, Issue 35, Pages 7363-7371Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3222-20.2021
Keywords
achromatopsia; color; plasticity; population-receptive field; vision; visual cortex
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Funding
- Yedidut Research Fund
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The study of two CNGA3-achromatopsia adults before and after ocular gene augmentation therapy revealed minor improvements behaviorally and cortically, but color perception still faced challenges either due to insufficient recovery at the retinal level or limitations in processing new cone-derived inputs in the adult cortex.
The ability of the adult human brain to develop function following correction of congenital deafferentation is controversial. Specifically, cases of recovery from congenital visual deficits are rare. CNGA3-achromatopsia is a congenital hereditary disease caused by cone-photoreceptor dysfunction, leading to impaired acuity, photoaversion, and complete color blindness. Essentially, these patients have rod-driven vision only, seeing the world in blurry shades of gray. We use the uniqueness of this rare disease, in which the cone-photoreceptors and afferent fibers are preserved but do not function, as a model to study cortical visual plastic-ity. We had the opportunity to study two CNGA3-achromatopsia adults (one female) before and after ocular gene augmentation therapy. Alongside behavioral visual tests, we used novel fMRI-based measurements to assess participants' early visual population receptive-field sizes and color regions. Behaviorally, minor improvements were observed, including reduction in photoaversion, marginal improvement in acuity, and a new ability to detect red color. No improvement was observed in color arrangement tests. Cortically, pretreatment, patients' population-receptive field sizes of early visual areas were untypically large, but were decreased following treatment specifically in the treated eye. We suggest that this demonstrates cortical ability to encode new input, even at adulthood. On the other hand, no activation of color-specific cortical regions was demonstrated in these patients either before or up to 1 year post-treatment. The source of this deficiency might be attributed either to insufficient recovery of cone function at the retinal level or to challenges that the adult cortex faces when computing new cone-derived input to achieve color perception.
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