Journal
JOURNAL OF NEUROLOGY
Volume 269, Issue 3, Pages 1236-1249Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00415-021-10597-4
Keywords
Complication; Depression; Neuropsychiatric disease; PSD; Stroke
Categories
Funding
- National Natural Science Foundation of China [U20A20357]
- Fundamental Research Funds for the Central Universities
Ask authors/readers for more resources
Post-stroke depression (PSD) is a common and serious sequelae of stroke, affecting functional rehabilitation and quality of life, and strongly related to high mortality. Various factors contribute to the occurrence of PSD, and a unified mechanism to explain PSD is currently lacking. Treatment options include pharmacotherapy and psychological therapies, but there are still unresolved issues, especially regarding the mechanism of PSD.
Post-stroke depression (PSD) is one of common and serious sequelae of stroke. Approximately, one in three stroke survivors suffered from depression after stroke. It heavily affected functional rehabilitation, which leaded to poor quality of life. What is worse, it is strongly associated with high mortality. In this review, we aimed to derive a comprehensive and integrated understanding of PSD according to recently published papers and previous classic articles. Based on the considerable number of studies, we found that within 2 years incidence of PSD has a range from 11 to 41%. Many factors contribute to the occurrence of PSD, including the history of depression, stroke severity, lesion location, and so on. Currently, the diagnosis of PSD is mainly based on the DSM guidelines and combined with various depression scales. Unfortunately, we lack a unified mechanism to explain PSD which mechanisms now involve dysregulation of hypothalamic-pituitary-adrenal (HPA) axis, increased inflammatory factors, decreased levels of monoamines, glutamate-mediated excitotoxicity, and abnormal neurotrophic response. At present, both pharmacotherapy and psychological therapies are employed in treating PSD. Although great advance has been made by researchers, there are still a lot of issues need to be addressed. Especially, the mechanism of PSD is not completely clear.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available