Journal
JOURNAL OF NEUROINTERVENTIONAL SURGERY
Volume 14, Issue 7, Pages -Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/neurintsurg-2021-017688
Keywords
aneurysm; MRI
Categories
Funding
- National Natural Science Foundation of China [82001804, 81901197, 31730039]
- Natural Science Foundation of Beijing Municipality [7191003]
- Ministry of Science and Technology of China [2019YFA0707103]
- Chinese Academy of Sciences [XDB32010300]
- US National Institutes of Health (NIH) [R00HL136883]
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This study utilized 7T MRI to quantify intracranial aneurysm wall thickness and enhancement, revealing that larger aneurysms had thicker walls and stronger enhancement. Aneurysm type did not significantly affect wall thickness.
Background This study was performed to quantify intracranial aneurysm wall thickness (AWT) and enhancement using 7T MRI, and their relationship with aneurysm size and type. Methods 27 patients with 29 intracranial aneurysms were included. Three-dimensional T1 weighted pre- and post-contrast fast spin echo with 0.4 mm isotropic resolution was used. AWT was defined as the full width at half maximum on profiles of signal intensity across the aneurysm wall on pre-contrast images. Enhancement ratio (ER) was defined as the signal intensity of the aneurysm wall over that of the brain parenchyma. The relationships between AWT, ER, and aneurysm size and type were investigated. Results 7T MRI revealed large variations in AWT (range 0.11-1.24 mm). Large aneurysms (>7 mm) had thicker walls than small aneurysms (<= 7 mm) (0.49 +/- 0.05 vs 0.41 +/- 0.05 mm, p<0.001). AWT was similar between saccular and fusiform aneurysms (p=0.546). Within each aneurysm, a thicker aneurysm wall was associated with increased enhancement in 28 of 29 aneurysms (average r=0.65, p<0.05). Thicker walls were observed in enhanced segments (ER >1) than in non-enhanced segments (0.53 +/- 0.09 vs 0.38 +/- 0.07 mm, p<0.001). Conclusion Improved image quality at 7T allowed quantification of intracranial AWT and enhancement. A thicker aneurysm wall was observed in larger aneurysms and was associated with stronger enhancement.
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