Modeling compartmentalized chronic immune-mediated demyelinating CNS disease in the Biozzi ABH mouse

We explored whether experimental autoimmune encephalomyelitis (EAE) in Biozzi mice recapitulates temporal dynamics of tissue injury, immune-pathogenesis and CNS compartmentalization occurring in progressive multiple sclerosis (MS). Chronic EAE exhibited relapsing and progressing disease, partial closure of BBB, reduced tissue inflammatory activity, and development of meningeal ectopic lymphoid tissue, directly opposing (potentially driving) spinal subpial demyelinated plaques. A T cell predominant disease during relapses transformed into a B cell predominant disease in late chronic EAE, with high serum anti-MOG reactivity. Thus, late chronic Biozzi EAE recapitulates essential features of progressive MS, and is suitable for developing disease modifying and regenerative therapies.

Automated summary

The study found that chronic EAE in Biozzi mice exhibits similar clinical features to progressive MS, including relapsing and progressing disease, partial closure of the blood-brain barrier, reduced tissue inflammatory activity, and the development of meningeal ectopic lymphoid tissue. Late chronic Biozzi EAE also transitions from a T cell predominant disease to a B cell predominant disease, with high serum anti-MOG reactivity, making it suitable for developing disease modifying and regenerative therapies.