Protective effect of scorpion venom heat-resistant synthetic peptide against PM2.5-induced microglial polarization via TLR4-mediated autophagy activating PI3K/AKT/NF-?B signaling pathway

There is growing evidence that fine particulate matter (PM2.5) is a considerable risk factor for neurodegenerative diseases. Scorpion venom heat-resistant synthetic peptide (SVHRSP) plays a neuroprotective effect by promoting neurogenesis and neuron axon growth. In this study, SVHRSP inhibited the level of TLR4, autophagy and PM2.5induced microglia M1 polarization, thereby promoting Phosphorylation of PI3K and AKT, inhibiting the expression of NF-?B. Moreover, SVHRSP suppressed the cytotoxic factors and increased the cytoprotective factor. This research demonstrates that SVHRSP relieves PM2.5-induced microglial polarization via TLR4-mediated autophagy activating PI3K/AKT/NF-?B signaling pathway, which provides new insights for the treatment of PM2.5-induced neurodegenerative diseases.

Automated summary

The study shows that SVHRSP inhibits PM2.5-induced microglial polarization by suppressing TLR4-mediated autophagy and activating the PI3K/AKT/NF-κB signaling pathway, thus providing new insights for the treatment of PM2.5-induced neurodegenerative diseases.