Journal
JOURNAL OF NEUROENGINEERING AND REHABILITATION
Volume 18, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12984-021-00897-1
Keywords
Parkinson's disease; Impulse control disorders; Electroencephalogram; Event-related potential; LEGO-like headset
Categories
Funding
- Collaborative Research Project of National Sun Yat-sen University
- Kaohsiung Chang Gung Memorial Hospital, Taiwan [CMRPG8I0371]
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The study found that a low-cost LEGO-like EEG headset successfully captured ERP waveforms in patients with PD undergoing DA treatment, providing objective assessment of ICD. This objective neuro-evidence could complement conventional clinical scales used to diagnose ICD adverse effects.
Background Patients with Parkinson's disease (PD) can develop impulse control disorders (ICDs) while undergoing a pharmacological treatment for motor control dysfunctions with a dopamine agonist (DA). Conventional clinical interviews or questionnaires can be biased and may not accurately diagnose at the early stage. A wearable electroencephalogram (EEG)-sensing headset paired with an examination procedure can be a potential user-friendly method to explore ICD-related signatures that can detect its early signs and progression by reflecting brain activity. Methods A stereotypical Go/NoGo test that targets impulse inhibition was performed on 59 individuals, including healthy controls, patients with PD, and patients with PD diagnosed by ICDs. We conducted two Go/NoGo sessions before and after the DA-pharmacological treatment for the PD and ICD groups. A low-cost LEGO-like EEG headset was used to record concurrent EEG signals. Then, we used the event-related potential (ERP) analytical framework to explore ICD-related EEG abnormalities after DA treatment. Results After the DA treatment, only the ICD-diagnosed PD patients made more behavioral errors and tended to exhibit the deterioration for the NoGo N2 and P3 peak amplitudes at fronto-central electrodes in contrast to the HC and PD groups. Particularly, the extent of the diminished NoGo-N2 amplitude was prone to be modulated by the ICD scores at Fz with marginal statistical significance (r = - 0.34, p = 0.07). Conclusions The low-cost LEGO-like EEG headset successfully captured ERP waveforms and objectively assessed ICD in patients with PD undergoing DA treatment. This objective neuro-evidence could provide complementary information to conventional clinical scales used to diagnose ICD adverse effects.
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