Journal
JOURNAL OF NATURAL PRODUCTS
Volume 84, Issue 8, Pages 2111-2120Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.1c00096
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Funding
- National Natural Science Foundation of China [81973193]
- Natural Science Foundation of Gansu [20JR5RA279]
- Funda-mental Research Funds for the Central Universities [lzujbky2019-ct03]
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A bioactivity-guided study on the leaves of Picrasma javanica resulted in the isolation of 19 quassinoids, including 13 new compounds. The structures of the new compounds were determined through a combination of spectroscopic analysis, X-ray crystallography, and ECD data interpretation. Some of the new compounds showed moderate inhibitory effects against phytopathogenic fungi, with compounds 6 and 15 exhibiting comparable activity to the positive control carbendazim. Additionally, preliminary structure-activity relationships of these quassinoids were investigated.
A bioactivity-guided study on the leaves of Picrasma javanica led to the isolation of 19 quassinoids, including 13 new compounds. The structures of the new compounds were elucidated by a combination of spectroscopic data analysis, X-ray crystallography studies, and electronic circular dichroism (ECD) data interpretation. Compounds 1-7 are rare examples of quassinoids with a keto carbonyl group at C-12. The biological activities of 11 of the more abundant isolates were evaluated against five phytopathogenic fungi in vitro, and several of them including 6 and 15 showed moderate inhibitory effects that were comparative to those of the positive control, carbendazim. In addition, the preliminary structure-activity relationships (SARs) of these quassinoids were also investigated.
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