Journal
JOURNAL OF NATURAL MEDICINES
Volume 76, Issue 1, Pages 102-109Publisher
SPRINGER JAPAN KK
DOI: 10.1007/s11418-021-01559-1
Keywords
Crocus sativus; Monoterpenoids; Structure elucidation; Anti inflammation activity
Categories
Funding
- 3-year development plan project for Traditional Chinese Medicine [ZY (2018-2020)-CCCX-2001-02]
- Key-Area Research and Development Program of GuangDong Province [2020B1111110003]
- National Major Scientific and Technological Special Project for Significant New Drugs Development [2019ZX09301140]
- NSFC [81803545, 81973438]
- Saffron Div. of the Shanghai Medicinal Material Co., Ltd.
Ask authors/readers for more resources
In this study, a new compound, crocusatin M, and three new glycosidic compounds, crocusatins N-P, were isolated from the dried stigmas of Crocus sativus. The structures of the new compounds were determined by spectroscopic analysis, with compounds 1 and 4 showing weak anti-inflammatory activities.
One new compound, crocusatin M (1), and three new glycosidic compounds, crocusatins N-P (2-4), along with nine known compounds were isolated from the dried stigmas of Crocus sativus. The structures of new compounds were elucidated on the basis of spectroscopic analysis, and the absolute configurations of 1, 2, and 3 were unambiguously assigned by the comparison of experimental and calculated ECD data. This is the first report of the isolation of 4 with the HMG moiety from the genus Crocus. Compounds 1 and 4 exhibited weak anti-inflammatory activities on inhibiting lipopolysaccharide (LPS)-induced NO production. [GRAPHICS] .
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
