Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1234, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.molstruc.2021.130193
Keywords
N-acylhydrazones; Silver complexes; Mycobacterium tuberculosis; Powder X-ray diffraction
Categories
Funding
- FAPEMIG [APQ-00481/17]
- CNPq [304275/2020-4, 303830/2017-4]
- FAPESP (Sao Paulo State Research Foundation-Brazil) [2018/12062-4, 2018/00163-0]
- Pro-Reitoria de Pesquisa/UNESP (PROPE) [0102/004/43]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) [001]
Ask authors/readers for more resources
This study describes the synthesis, characterization, and antitubercular assays of N-acylhydrazones derivatives and their corresponding silver(I) complexes. The compounds were characterized using various analytical techniques, and displayed promising activities against M. tuberculosis, including multidrug-resistant clinical strains. The cytotoxic activity assays revealed high selectivity indexes for all compounds over MRC-5 cells.
In the present work, synthesis, characterization and antitubercular assays of N-acylhydrazones derivatives and their corresponding silver(I) complexes are described. The compounds were characterized by elemental analysis, IR and NMR spectroscopic measurements, molar conductivity assays and powder diffraction X ray studies. Some of the synthesized compounds have shown minimum inhibitory concentration (MIC90) values against M. tuberculosis H37Rv (ATCC 27294) lower than 0.098 mu g/mL, while the cytotoxic activity assays over MRC-5 cells reveled that all compounds present selectivity indexes higher than 27. Furthermore, N-acylhydrazones compounds showed promising activities even against multidrug-resistant clinical strains of M. tuberculosis. (C) 2021 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
