Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1236, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.molstruc.2021.130305
Keywords
Hydrazone; Febuxostat; Larvicidal; Single-crystal X-ray; Anopheles arabiensis; Carbohydrazide
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The study focused on synthesizing novel hydrazone compounds and evaluating their larvicidal activity against Anopheles arabiensis. Compounds (5a) and (5g) were found to be promising larvicidal agents against the mosquito species.
The present study focuses on a series of novel hydrazones of 2-[3-cyano-4-(2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carbohydrazide (5a-l) for their larvicidal activity against Anopheles arabiensis. The synthesis of the title compounds was achieved by the conventional reflux method, and structures of the novel compounds were ascertained by FT-IR, NMR (H-1&C-13), LC-MS, and elemental analysis. Compound (5l) was studied by single crystal X-ray diffraction for intra and intermolecular interactions. Title compounds (E)-2-(3-cyano-4-isobutoxyphenyl)-N'-(4-fluoro-3-phenoxybenzylidene)-4-methylthiazole-5-carbohydrazide (5a) and (E)-N'-(4-Chlorobenzylidene)-2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carbohydrazide (5g) emerged as promising larvicidal agents against Anopheles arabiensis. (C) 2021 Elsevier B.V. All rights reserved.
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