Journal
JOURNAL OF MOLECULAR MEDICINE-JMM
Volume 99, Issue 11, Pages 1553-1569Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00109-021-02123-w
Keywords
Aging; Alzheimer's; Cellular senescence; Immune tolerance; Immunosuppression; Kynurenine
Funding
- University of Eastern Finland (UEF) including Kuopio University Hospital
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The functional competence of the immune system declines with aging, leading to immunosenescence. Involving both adaptive and innate immunity, immunosenescence is associated with chronic inflammation and a state called inflammaging. This process also occurs in pathological conditions, where persistent inflammation triggers compensatory immunosuppression.
The functional competence of the immune system gradually declines with aging, a process called immunosenescence. The age-related remodelling of the immune system affects both adaptive and innate immunity. In particular, a chronic low-grade inflammation, termed inflammaging, is associated with the aging process. Immunosenescence not only is present in inflammaging state, but it also occurs in several pathological conditions in conjunction with chronic inflammation. It is known that persistent inflammation stimulates a counteracting compensatory immunosuppression intended to protect host tissues. Inflammatory mediators enhance myelopoiesis and induce the generation of immature myeloid-derived suppressor cells (MDSC) which in mutual cooperation stimulates the immunosuppressive network. Immunosuppressive cells, especially MDSCs, regulatory T cells (Treg), and M2 macrophages produce immunosuppressive factors, e.g., TGF-beta, IL-10, ROS, arginase-1 (ARG1), and indoleamine 2,3-dioxygenase (IDO), which suppress the functions of CD4/CD8T and B cells as well as macrophages, natural killer (NK) cells, and dendritic cells. The immunosuppressive armament (i) inhibits the development and proliferation of immune cells, (ii) decreases the cytotoxic activity of CD8T and NK cells, (iii) prevents antigen presentation and antibody production, and (iv) suppresses responsiveness to inflammatory mediators. These phenotypes are the hallmarks of immunosenescence. Immunosuppressive factors are able to control the chromatin landscape, and thus, it seems that the immunosenescence state is epigenetically regulated.
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