Journal
JOURNAL OF MOLECULAR LIQUIDS
Volume 334, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.molliq.2021.116141
Keywords
Biological membranes; Lipid bilayers; Lipid membrane models; Membrane mimetic models; Artificial membranes
Funding
- Laboratory for Process Engineering, Environment, Biotechnology and Energy - LEPABE - FCT/MCTES (PIDDAC) [UIDB/00511/2020]
- European Union's Horizon 2020 research and innovation program [810685]
- Santa Casa da Misericordia de Lisboa [MB37-2017]
- Prize Maratona da Saude for Cancer Research
- Fundacao para a Ciencia e a Tecnologia - FCT [SFRH/BD/129312/2017, CEECINST/00049/2018]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/129312/2017] Funding Source: FCT
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Understanding how drugs interact with biological membranes is crucial for the pharmaceutical industry. In vitro lipid-based membrane models provide a simple alternative to study these interactions. Different lipid models and biophysical methodologies using liposomes are discussed for investigating drug-membrane interactions.
The interaction of drugs with biological membranes is a critical factor affecting their pharmacokinetics and pharmacodynamics, so understanding how drugs interact with biomembranes is of valuable interest for the pharmaceutical industry. However, such interactions are difficult to investigate due to the complexity of biological membranes, mainly related to the dynamic structure of membranes that are composed of wide variety of molecules. In this context, in vitro lipid-based membrane models emerged to offer a simple yet useful alternative way of studying drug-membrane interactions. Different lipid models can be used as in vitro biomembrane models, and this review presents a brief overview of the most promising membrane models used in this field. Also, the most used biophysical methodologies to study drugs' and membranes' properties using liposomes are reviewed. The significance of using liposomes as lipid membrane models to investigate drug-membrane interactions is discussed and future perspectives are presented. (C) 2021 Published by Elsevier B.V.
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