Scrutinizing the Micellization Behaviour of 14-2-14 Gemini Surfactant and Tetradecyltrimethylammonium Bromide in Aqueous Solutions of Betaine Hydrochloride Drug

In the present work, we investigated the effect of drug Betaine Hydrochloride (Betaine HCl) on the aggregation behavior of ethylene-1, 2-bis (N, N-dimethyl-N-tetradecylammonium bromide) (14-2-14) and tetradecyltrimethylammonium bromide (TTAB) by employing electrical conductivity and FT-IR spectroscopic techniques. Initially, synthesis of 14-2-14 is carried out in laboratory followed by determination of critical micelle concentration (CMC) through electrical conductivity measurements at temperatures 293.15 K, 298.15 K, 303.15 K, 308.15 K in absence and presence of Betaine HCl at concentrations 0.10 mmol/kg, 0.15 mmol/kg and 0.25 mmol/kg. The decrement in CMC value is observed with increasing concentrations of Betaine HCl as well as with decreasing temperatures. Several thermodynamic parameters such as the standard enthalpy of micellization (Delta H-m(0)), the standard entropy of micellization (Delta S-m(0)) and the standard Gibbs energy of micellization (Delta G(m)(0)), etc. have been evaluated using values of CMC for various concentrations of Betaine HCl at different temperatures. The alterations instigated in respective have been recognized by FT-IR spectroscopic analysis, which signifies the variations produced by the drug on the aggregation of the surfactants (14-2-14 and TTAB) in aqueous media. (C) 2021 Elsevier B.V. All rights reserved.

Automated summary

In this study, the impact of the drug Betaine Hydrochloride on the aggregation behavior of two surfactants was investigated using electrical conductivity and FT-IR spectroscopic techniques. It was found that the critical micelle concentration decreased with increasing concentrations of Betaine HCl and decreasing temperatures. Thermodynamic parameters were evaluated and changes in aggregation behavior were confirmed through FT-IR spectroscopic analysis.