Related references
Note: Only part of the references are listed.CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia
Joshua D. Hansen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
Molecular glue concept solidifies
Kheewoong Baek et al.
NATURE CHEMICAL BIOLOGY (2020)
Crystal structure of the SALL4-pomalidomide-cereblon-DDB1 complex
Mary E. Matyskiela et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2020)
Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer's Disease Progression (vol 105, pg 975, 2020)
Bing Bai et al.
NEURON (2020)
Targeted protein degradation: current and future challenges
Alexander Hanzl et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2020)
Production of Lentiviral Vectors Using Suspension Cells Grown in Serum-free Media
Matthew Bauler et al.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT (2020)
High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds using HiBiT CRISPR Cell Lines
Kristin M. Riching et al.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2020)
Patterns of substrate affinity, competition, and degradation kinetics underlie biological activity of thalidomide analogs
Adam S. Sperling et al.
BLOOD (2019)
Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders
Jiuling Yang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Development of targeted protein degradation therapeutics
Philip P. Chamberlain et al.
NATURE CHEMICAL BIOLOGY (2019)
CC-90009, a Novel Cereblon E3 Ligase Modulator, Targets GSPT1 for Degradation to Induce Potent Tumoricidal Activity Against Acute Myeloid Leukemia (AML)
Antonia Lopez-Girona et al.
BLOOD (2019)
Comprehensive Genomic Profiling of Pediatric Therapy-Related Myeloid Neoplasms Identifies Mecom Dysregulation to be Associated with Poor Outcome
Jason R. Schwartz et al.
BLOOD (2019)
Targeted protein degradation: expanding the toolbox
Matthieu Schapira et al.
NATURE REVIEWS DRUG DISCOVERY (2019)
Elucidating the Mechanism of Action of CC-90009, a Novel Cereblon E3 Ligase Modulator, in AML Via Genome-Wide CRISPR Screen
Gang Lu et al.
BLOOD (2019)
Targeting the undruggable: exploiting neomorphic features of fusion oncoproteins in childhood sarcomas for innovative therapies
Maximilian M. L. Knott et al.
CANCER AND METASTASIS REVIEWS (2019)
Targeting transcription factors in cancer - from undruggable to reality
John H. Bushweller
NATURE REVIEWS CANCER (2019)
CRIS.py: A Versatile and High-throughput Analysis Program for CRISPR-based Genome Editing
Jon P. Connelly et al.
SCIENTIFIC REPORTS (2019)
A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos
Mary E. Matyskiela et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Protein Degradation via CRL4CRBN Ubiquitin Ligase: Discovery and Structure-Activity Relationships of Novel Glutarimide Analogs That Promote Degradation of Aiolos and/or GSPT1
Joshua D. Hansen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Translation Termination Factor GSPT1 Is a Phenotypically Relevant Off-Target of Heterobifunctional Phthalimide Degraders
Mette Ishoey et al.
ACS CHEMICAL BIOLOGY (2018)
The many faces of IKZF1 in B-cell precursor acute lymphoblastic leukemia
Rene Marke et al.
HAEMATOLOGICA (2018)
Plasticity in binding confers selectivity in ligand-induced protein degradation
Radoslaw P. Nowak et al.
NATURE CHEMICAL BIOLOGY (2018)
A Survey of Validation Strategies for CRISPR-Cas9 Editing
Monica F. Sentmanat et al.
SCIENTIFIC REPORTS (2018)
The many faces of IKZF1 in B-cell precursor acute lymphoblastic leukemia
Rene Marke et al.
HAEMATOLOGICA (2018)
The genetic basis and cell of origin of mixed phenotype acute leukaemia
Thomas B. Alexander et al.
NATURE (2018)
Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases
Jian-Feng Li et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN
Quinlan L. Sievers et al.
SCIENCE (2018)
The whole-genome landscape of medulloblastoma subtypes
Paul A. Northcott et al.
NATURE (2017)
Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15
Ting Han et al.
SCIENCE (2017)
Small-Molecule PROTACS: New Approaches to Protein Degradation
Momar Toure et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
Review: Aberrant EVI1 expression in acute myeloid leukaemia
Adil A. Hinai et al.
BRITISH JOURNAL OF HAEMATOLOGY (2016)
A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase
Mary E. Matyskiela et al.
NATURE (2016)
Exploring genomic alteration in pediatric cancer using ProteinPaint
Xin Zhou et al.
NATURE GENETICS (2016)
miRNA-144 suppresses proliferation and migration of colorectal cancer cells through GSPT1
Ruilin Xiao et al.
BIOMEDICINE & PHARMACOTHERAPY (2015)
Recurrent deletions of IKZF1 in pediatric acute myeloid leukemia
Jasmiji D. E. de Rooji et al.
HAEMATOLOGICA (2015)
Lenalidomide induces ubiquitination and degradation of CK1a in del(5q) MDS
Jan Kroenke et al.
NATURE (2015)
Recurrent deletions of IKZF1 in pediatric acute myeloid leukemia
Jasmiji D. E. de Rooji et al.
HAEMATOLOGICA (2015)
BET Bromodomain Inhibition of MYC-Amplified Medulloblastoma
Pratiti Bandopadhayay et al.
CLINICAL CANCER RESEARCH (2014)
Nicotine-mediated invasion and migration of non-small cell lung carcinoma cells by modulating STMN3 and GSPT1 genes in an ID1-dependent manner
Sajitha Nair et al.
MOLECULAR CANCER (2014)
Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma
Paul A. Northcott et al.
NATURE (2014)
Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells
Jan Kroenke et al.
SCIENCE (2014)
Target validation using chemical probes
Mark E. Bunnage et al.
NATURE CHEMICAL BIOLOGY (2013)
Synthesis, structural, spectroscopic studies, NBO analysis, NLO and HOMO-LUMO of 4-methyl-N-(3-nitrophenyl)benzene sulfonamide with experimental and theoretical approaches
K. Sarojini et al.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2013)
Role of MYC in Medulloblastoma
Martine F. Roussel et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2013)
HD-MB03 is a novel Group 3 medulloblastoma model demonstrating sensitivity to histone deacetylase inhibitor treatment
Till Milde et al.
JOURNAL OF NEURO-ONCOLOGY (2012)
The Ikaros gene family: Transcriptional regulators of hematopoiesis and immunity
Liza B. John et al.
MOLECULAR IMMUNOLOGY (2011)
Differential expression of GSPT1 GGCn alleles in cancer
Joana Malta-Vacas et al.
CANCER GENETICS AND CYTOGENETICS (2009)
Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia
Charles G. Mullighan et al.
NATURE GENETICS (2009)
eRF3a/GSPT1 12-GGC allele increases the susceptibility for breast cancer development
Joana Malta-Vacas et al.
ONCOLOGY REPORTS (2009)
G1 to S phase transition protein 1 induces apoptosis signal-regulating kinase 1 activation by dissociating 14-3-3 from ASK1
J. A. Lee et al.
ONCOGENE (2008)
The influence of drug-like concepts on decision-making in medicinal chemistry
Paul D. Leeson et al.
NATURE REVIEWS DRUG DISCOVERY (2007)
Human eukaryotic release factor 3a depletion causes cell cycle arrest at G1 phase through inhibition of the mTOR pathway
Celine Chauvin et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Differential expression of the eukaryotic release factor 3 (eRF3/GSPT1) according to gastric cancer histological types
J Malta-Vacas et al.
JOURNAL OF CLINICAL PATHOLOGY (2005)