4.7 Article

Discovery of AS-1763: A Potent, Selective, Noncovalent, and Orally Available Inhibitor of Bruton's Tyrosine Kinase

Related references

Note: Only part of the references are listed.
Review Oncology

Targeting Bruton tyrosine kinase using non-covalent inhibitors in B cell malignancies

Danling Gu et al.

Summary: B cell receptor signaling plays a key role in the pathogenesis of B cell malignancies, with Bruton tyrosine kinase (BTK) being a critical component. While covalent BTK inhibitors have shown significant efficacy, acquired resistance and adverse events necessitate the exploration of alternative therapeutic options. Non-covalent BTK inhibitors may provide an effective choice, especially for patients who have developed resistance to covalent inhibitors.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

Article Medicine, General & Internal

Pirtobrutinib in relapsed or refractory B-cell malignancies (BRUIN): a phase 1/2 study

Anthony R Mato et al.

LANCET (2021)

Review Biotechnology & Applied Microbiology

Ibrutinib in Chronic Lymphocytic Leukemia: Clinical Applications, Drug Resistance, and Prospects

Hong Zhou et al.

ONCOTARGETS AND THERAPY (2020)

Article Chemistry, Medicinal

Design and synthesis of novel pyrimidine analogs as highly selective, non-covalent BTK inhibitors

Wataru Kawahata et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)

Review Biochemistry & Molecular Biology

Role of Bruton's tyrosine kinase in B cells and malignancies

Simar Pal Singh et al.

MOLECULAR CANCER (2018)

Meeting Abstract Oncology

LOXO-305, A Next Generation Reversible BTK Inhibitor, for Overcoming Acquired Resistance to Irreversible BTK Inhibitors

Barbara Brandhuber et al.

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA (2018)

Review Chemistry, Multidisciplinary

Oxetanes: Recent Advances in Synthesis, Reactivity, and Medicinal Chemistry

James A. Bull et al.

CHEMICAL REVIEWS (2016)

Article Oncology

Ibrutinib: a first in class covalent inhibitor of Bruton's tyrosine kinase

Matthew S. Davids et al.

FUTURE ONCOLOGY (2014)

Article Medicine, General & Internal

Resistance Mechanisms for the Bruton's Tyrosine Kinase Inhibitor Ibrutinib

Jennifer A. Woyach et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Review Oncology

Targeting Bruton's tyrosine kinase in B cell malignancies

Rudi W. Hendriks et al.

NATURE REVIEWS CANCER (2014)

Article Multidisciplinary Sciences

The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

Lee A. Honigberg et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Chemistry, Medicinal

Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase

Zhengying Pan et al.

CHEMMEDCHEM (2007)

Article Chemistry, Organic

Aqueous-phase Suzuki-Miyaura cross-coupling reactions of free halopurine bases

Petr Capek et al.

SYNTHESIS-STUTTGART (2006)

Review Immunology

Functional dissection of BCR signaling pathways

T Kurosaki

CURRENT OPINION IN IMMUNOLOGY (2000)