Related references
Note: Only part of the references are listed.Ubiquitin-dependent degradation of CDK2 drives the therapeutic differentiation of AML by targeting PRDX2
Meidan Ying et al.
BLOOD (2018)
Comprehensive Characterization of Cancer Driver Genes and Mutations
Matthew H. Bailey et al.
CELL (2018)
Identification of CDK2 as a novel target in treatment of prostate cancer
Xifeng Yin et al.
FUTURE ONCOLOGY (2018)
How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases?
Radek Jorda et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Broad-Spectrum Kinase Profiling in Live Cells with Lysine-Targeted Sulfonyl Fluoride Probes
Qian Zhao et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
Cyclin-Dependent Kinase 2 Promotes Tumor Proliferation and Induces Radio Resistance in Glioblastoma
Jia Wang et al.
TRANSLATIONAL ONCOLOGY (2016)
HOXA7 stimulates human hepatocellular carcinoma proliferation through cyclin E1/CDK2
Yuehui Li et al.
ONCOLOGY REPORTS (2015)
Tumor Suppression by the Fbw7 Ubiquitin Ligase: Mechanisms and Opportunities
Ryan J. Davis et al.
CANCER CELL (2014)
Frequent CCNE1 amplification in endometrial intraepithelial carcinoma and uterine serous carcinoma
Elisabetta Kuhn et al.
MODERN PATHOLOGY (2014)
Cyclin-dependent kinases
Marcos Malumbres
GENOME BIOLOGY (2014)
Cdks, cyclins and CKIs: roles beyond cell cycle regulation
Shuhui Lim et al.
DEVELOPMENT (2013)
Lipophilic efficiency: the most important efficiency metric in medicinal chemistry
Kevin D. Freeman-Cook et al.
FUTURE MEDICINAL CHEMISTRY (2013)
Radical-Based Regioselective C-H Functionalization of Electron-Deficient Heteroarenes: Scope, Tunability, and Predictability
Fionn O'Hara et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
Maximizing Lipophilic Efficiency: The Use of Free-Wilson Analysis in the Design of Inhibitors of Acetyl-CoA Carboxylase
Kevin D. Freeman-Cook et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
A New Reagent for Direct Difluoromethylation
Yuta Fujiwara et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Hallmarks of Cancer: The Next Generation
Douglas Hanahan et al.
CELL (2011)
Development of a New Permeability Assay Using Low-Efflux MDCKII Cells
Li Di et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2011)
Cyclin D as a therapeutic target in cancer
Elizabeth A. Musgrove et al.
NATURE REVIEWS CANCER (2011)
Capillary microfluidic electrophoretic mobility shift assays: application to enzymatic assays in drug discovery
Dominique Perrin et al.
EXPERT OPINION ON DRUG DISCOVERY (2010)
Using the Golden Triangle to optimize clearance and oral absorption
Ted W. Johnson et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Defining optimum lipophilicity and molecular weight ranges for drug candidates-Molecular weight dependent lower logD limits based on permeability
Michael J. Waring
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
A Consistent Dataset of Kinetic Solubilities for Early-Phase Drug Discovery
Christian Kramer et al.
CHEMMEDCHEM (2009)
Pharmacological Promiscuity: Dependence on Compound Properties and Target Specificity in a Set of Recent Roche Compounds
Jens-Uwe Peters et al.
CHEMMEDCHEM (2009)
Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells
Jan J. Molenaar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Cell cycle, CDKs and cancer: a changing paradigm
Marcos Malumbres et al.
NATURE REVIEWS CANCER (2009)
Cdk1 is sufficient to drive the mammalian cell cycle
David Santamaria et al.
NATURE (2007)
Peripheral white blood cell toxicity induced by broad spectrum cyclin-dependent kinase inhibitors
Bart A. Jessen et al.
JOURNAL OF APPLIED TOXICOLOGY (2007)
Cyclin E expression is correlated with tumor progression and predicts a poor prognosis in patients with ovarian carcinoma
DG Rosen et al.
CANCER (2006)
Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6
PL Toogood et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Pyrido[2,3-d]pyrimidin-7-ones as specific inhibitors of cyclin-dependent kinase 4
SN VanderWel et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Determination of accurate KI values for tight-binding enzyme inhibitors:: an in silico study of experimental error and assay design
DJ Murphy
ANALYTICAL BIOCHEMISTRY (2004)
Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF
JY Du et al.
CANCER CELL (2004)
To cycle or not to cycle: A critical decision in cancer
M Malumbres et al.
NATURE REVIEWS CANCER (2001)
Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases
M Barvian et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)
Share Paper
