4.7 Article

Ivermectin: A Promising Therapeutic for Fighting Malaria. Current Status and Perspective

Journal

JOURNAL OF MEDICINAL CHEMISTRY
Volume 64, Issue 14, Pages 9711-9731

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.jmedchem.1c00498

Keywords

-

Funding

  1. SERB, DST [EMR/2017/000520]
  2. Guru Nanak Dev University, Amritsar
  3. University Grants Commission (UGC), New Delhi

Ask authors/readers for more resources

This review highlights the efficacy of ivermectin in controlling malaria through vector control and effective chemoprevention to reduce parasite transmission and related fatalities.
Finding new chemotherapeutic interventions to treat malaria through repurposing of time-tested drugs and rigorous design of new drugs using tools of rational drug design remains one of the most sought strategies at the disposal of medicinal chemists. Ivermectin, a semisynthetic derivative of avermectin B-1, is among the efficacious drugs used in mass drug administration drives employed against onchocerciasis, lymphatic filariasis, and several other parasitic diseases in humans. In this review, we present the prowess of ivermectin, a potent endectocide, in the control of malaria through vector control to reduce parasite transmission combined with efficacious chemoprevention to reduce malaria-related fatalities.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available