Journal
JOURNAL OF MEDICAL VIROLOGY
Volume 94, Issue 1, Pages 380-383Publisher
WILEY
DOI: 10.1002/jmv.27274
Keywords
COVID-19; disease severity; IgG; SARS-CoV-2; serology
Categories
Funding
- Huanggang Municipal Headquarters for COVID-19 Epidemic Prevention and Control, Key Project of Hunan Provincial Science and Technology Innovation [2020SK1011, 2020SK1010]
- Program of Hunan Science and Technology Department [2020SK3011]
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The level of virus-specific IgG antibodies is positively correlated with the severity of COVID-19, with the highest titers observed in severe cases. Asymptomatic carriers tended to have lower or even negative anti-SARS-CoV-2 IgG test results.
The durability of infection-induced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity has crucial implications for reinfection and vaccine effectiveness. However, the relationship between coronavirus disease 2019 (COVID-19) severity and long-term anti-SARS-CoV-2 immunoglobulin G (IgG) antibody level is poorly understood. Here, we measured the longevity of SARS-CoV-2-specific IgG antibodies in survivors who had recovered from COVID-19 1 year previously. In a cohort of 473 survivors with varying disease severity (asymptomatic, mild, moderate, or severe), we observed a positive correlation between virus-specific IgG antibody titers and COVID-19 severity. In particular, the highest virus-specific IgG antibody titers were observed in patients with severe COVID-19. By contrast, 74.4% of recovered asymptomatic carriers had negative anti-SARS-CoV-2 IgG test results, while many others had very low virus-specific IgG antibody titers. Our results demonstrate that SARS-CoV-2-specific IgG persistence and titer depend on COVID-19 severity.
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