Journal
JOURNAL OF MEDICAL PRIMATOLOGY
Volume 50, Issue 5, Pages 270-272Publisher
WILEY
DOI: 10.1111/jmp.12536
Keywords
aging; animal model; cognitive; non-human primates; sex hormone
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Funding
- Ministry of Finance of The Republic of Indonesia on The Research and Productive Innovation (RISPRO) LPDP program [PRJ/29/LPDP/2019]
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The study showed that aged memory-impaired cynomolgus monkeys had significantly lower levels of cerebrospinal amyloid (Aβ(42)) and serum testosterone compared to young animals and non-memory-impaired controls, confirming their potential as a model for aging-associated senile dementia of the Alzheimer type.
Aged memory-impaired cynomolgus monkeys had significantly lower levels of cerebrospinal amyloid (A beta(42)) and serum testosterone compared with young animals and non-memory-impaired controls. Our findings confirm similar findings in the human and substantiate the usefulness of the cynomolgus monkey as a spontaneous model for aging-associated senile dementia of the Alzheimer type.
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