Journal
FOOD RESEARCH INTERNATIONAL
Volume 82, Issue -, Pages 112-120Publisher
ELSEVIER
DOI: 10.1016/j.foodres.2016.01.022
Keywords
Anchovy protein hydrolysate; Maillard reaction; Memory-improving; Acetylcholinergic system; mRNA expression
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Funding
- Strategic Emerging Industry Key Scientific and Technological Program of Guangdong Province [2012A020800002, 2012A080800014]
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Anchovy (Coilia mystus) protein hydrolysate (APH) and its Maillard reaction product (APH-M) with D-ribose were subjected to in vivo mouse behavioral trials and associated with biochemical analyses, in vitro H2O2-stressed PC12 cell assay and inhibition of acetylcholin esterase (AchE) to explore the mechanism of the behavioral trial findings. Results revealed that both APH and APH-M could alleviate undesired alterations on hippocampus ultrastructure of mice, protect PC12 from H2O2-induced oxidative stress, and inhibit AchE activity in vivo and in vitro, suggesting the well-being potential for combating memory-impairment in mice. Moreover, APH-M exhibited much stronger abilities above than APH. The test of acatylcholinergic system indicated that APH-M would improve memory mainly through regulating the AchE activity, while APH through controlling the mRNA expression of ChAT and AchE activity. Therefore, protein hydrolysates from anchovy could possess therapeutic potential for memory deficits, and Maillard reaction might further promote their memory-improving capacity. (C) 2016 Elsevier Ltd. All rights reserved.
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