4.5 Review

Metabolic reprogramming of myeloid-derived suppressor cells: An innovative approach confronting challenges

Journal

JOURNAL OF LEUKOCYTE BIOLOGY
Volume 110, Issue 2, Pages 257-270

Publisher

OXFORD UNIV PRESS
DOI: 10.1002/JLB.1MR0421-597RR

Keywords

MDSCs; metabolic reprogramming; immune homeostasis; microenvironment

Funding

  1. Natural Science Foundation of China [82000194, 81730008]
  2. Zhejiang Provincial Natural Science Foundation of China [LQ19H080006]
  3. Zhejiang Key R&D Program (Science and Technology Department) [2019C03016]

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This review discusses the metabolic reprogramming of MDSCs in cancer and inflammation-derived microenvironment and the impact of core metabolic pathways on their phenotype and functions in various pathological conditions.
Immune cells such as T cells, macrophages, dendritic cells, and other immunoregulatory cells undergo metabolic reprogramming in cancer and inflammation-derived microenvironment to meet specific physiologic and functional demands. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that are characterized by immunosuppressive activity, which plays a key role in host immune homeostasis. In this review, we have discussed the core metabolic pathways, including glycolysis, lipid and fatty acid biosynthesis, and amino acid metabolism in the MDSCs under various pathologic situations. Metabolic reprogramming is a determinant of the phenotype and functions of MDSCs, and is therefore a novel therapeutic possibility in various diseases.

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