Journal
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume 141, Issue 9, Pages 2105-2107Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jid.2021.02.011
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Polyamines play a critical role in keratinocyte differentiation, with AMD1 mediating the shift in polyamine ratios. Targeting polyamine availability may be beneficial in treating hyperproliferative skin disorders.
Polyamines have been implicated in skin tumorigenesis; however, their role in epidermal homeostasis remains obscure. In a new article in the Journal of Investigative Dermatology, Rahim et al. (2021) report that keratinocyte differentiation requires a shift in polyamine ratios that is mediated by AMD1. Results suggest that targeting polyamine availability might be useful in the treatment of hyperproliferative skin disorders.
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