4.7 Review

CD1-Restricted T Cells in Inflammatory Skin Diseases

Journal

JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume 142, Issue 3 PT B, Pages 768-773

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.jid.2021.03.033

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Funding

  1. National Institutes of Health [R01AI145345, R01AI057460]

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This review discusses the role of CD1-restricted T cells in autoimmune skin conditions, including their recognition of self-lipids and aberrant regulation mechanisms.
Autoimmunity results from the breaking of immune tolerance, leading to inflammation and pathology. Although well studied in the conventional T-cell field, the role of nonconventional T cells in autoimmunity is less understood. CD1-restricted T cells recognize lipid antigens rather than peptide antigens and have been implicated in various autoimmune skin conditions, including psoriasis and atopic dermatitis. In this review, we will discuss the self-lipids that CD1-restricted T cells recognize and how these T cells become aberrantly regulated in pathogenic skin conditions.

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