Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 225, Issue 4, Pages 637-649Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiab444
Keywords
4CMenB; meningococcal; carriage; Neisseria meningitidis; herd protection
Categories
Funding
- GlaxoSmithKline Biologicals SA
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The study showed that increased uptake of 4CMenB vaccine in adolescents did not lead to a decline in carriage of disease-associated meningococci. Therefore, 4CMenB immunization programs should focus more on providing direct protection for groups at highest risk of the disease.
Background. Recombinant protein-based vaccines targeting serogroup B meningococci protect against invasive disease but impacts on carriage are uncertain. This study assessed carriage prevalence of disease-associated meningococci in 2018-2020 as the proportion of vaccinated adolescents increased following introduction of a school-based 4CMenB immunization program. Methods. Eligible participants who completed high school (aged 17-25) in South Australia in the previous year had an oropharyngeal swab taken and completed a risk factor questionnaire. Disease-associated meningococci (genogroups A, B, C, W, X, Y) were detected by meningococcal and genogroup-specific polymerase chain reaction. Results. The analysis included 4104 participants in 2018, 2690 in 2019, and 1338 in 2020. The proportion vaccinated with 4CMenB increased from 43% in 2018, to 78% in 2019, and 76% in 2020. Carriage prevalence of disease-associated meningococci in 2018 was 225/4104 (5.5%). There was little difference between carriage prevalence in 2019 (134/2690, 5.0%; adjusted odds ratio [aOR], 0.82; 95% confidence interval [CI],.64-1.05) and 2020 (68/1338, 5.1%; aOR, 0.82; 95% CI,.57-1.17) compared to 2018. Conclusions. Increased 4CMenB uptake in adolescents was not associated with decline in carriage of disease-associated meningococci. 4CMenB immunization programs should focus on direct (individual) protection for groups at greatest risk of disease.
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