Persistence of Neutralizing Antibody Response up to 1 Year After Asymptomatic or Symptomatic SARS-CoV-2 Infection

Editorial Material Infectious Diseases

Definitions for coronavirus disease 2019 reinfection, relapse and PCR re-positivity Comment

Dafna Yahav et al.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

Article Multidisciplinary Sciences

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

Jennifer M. Dan et al.

Summary: Different components of immune memory to SARS-CoV-2 exhibit distinct kinetics, with antibodies and spike-specific memory B cells remaining relatively stable over 6 months, while CD4(+) T cells and CD8(+) T cells declining with a half-life of 3 to 5 months after infection.

SCIENCE (2021)

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Article Cell Biology

Stereotypic neutralizing VH antibodies against SARS-CoV-2 spike protein receptor binding domain in patients with COVID-19 and healthy individuals

Sang Il Kim et al.

Summary: SARS-CoV-2 patients have stereotypic antibody clonotypes targeting the virus spike protein, which may provide protective immunity by neutralizing the virus. These clonotypes also exist in some healthy individuals, suggesting they can develop from naïve B cells rather than memory B cells from prior exposure to similar viruses.

SCIENCE TRANSLATIONAL MEDICINE (2021)

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Article Immunology

Antibody Responses 8 Months after Asymptomatic or Mild SARS-CoV-2 Infection

Pyoeng Gyun Choe et al.

Summary: A study investigated antibody responses of 58 individuals 8 months after infection with severe acute respiratory syndrome coronavirus 2, showing high seropositivity rates for 3 out of 4 immunoassays used.

EMERGING INFECTIOUS DISEASES (2021)

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Letter Immunology

Waning Antibody Responses in Asymptomatic and Symptomatic SARS-CoV-2 Infection

Pyoeng Gyun Choe et al.

Summary: The kinetics of SARS-CoV-2 neutralizing antibodies were investigated in asymptomatic individuals and pneumonia patients, showing a decline in antibody titer from 219.4 at 2 months to 143.7 at 5 months after infection, indicating a waning antibody response.

EMERGING INFECTIOUS DISEASES (2021)

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Article Medicine, General & Internal