Enhanced bone regeneration using poly(trimethylene carbonate)/vancomycin hydrochloride porous microsphere scaffolds in presence of the silane coupling agent modified hydroxyapatite nanoparticles

Tissue-engineered scaffolds acted as active natural extracellular matrices that allowed for cell attachment, migration, proliferation, and differentiation. To enhance the drug loading, degradation control, and mechanical features of tissue-engineered scaffolds used in bone regeneration applications, we synthesized novel poly(trimethylene carbonate) (PTMC)/modified HA nanoparticles (KHA NPs, modified by silane coupling agent)/vancomycin hydrochloride (VH) porous microspheres scaffold. The fabricated PTMC/KHA/VH scaffold has unique surface corrosion degradation, excellent surface properties, and high cytocompatibility. The novel PTMC/KHA/VH scaffold was characterized by 42% porosity, 100 mm pore size, and 208.2 MPa compressive modulus. After the treatment of a rat femur defect for 4, 8, and 12 weeks, the surface corrosion biodegraded of the PTMC/KHA/VH scaffold remarkably decreased inflammation response and promoted bone regeneration, suggesting its use as a bioactive structure in bone tissue engineering. (C) 2021 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

Automated summary

A novel PTMC/KHA/VH scaffold with unique surface properties and high cytocompatibility was synthesized, and after treating rat femur defects, it was found to significantly reduce inflammation response and promote bone regeneration.