Journal
JOURNAL OF HYPERTENSION
Volume 39, Issue 11, Pages 2128-2138Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/HJH.0000000000002928
Keywords
arterial stiffness; cardio-ankle vascular index; CAVI(0); pressure-dependency; pulse wave velocity
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Funding
- European Union's Horizon 2020 Research and Innovation program [793805]
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Studies indicate that CAVI(0) may enhance the pressure-independent assessment of arterial stiffness compared to CAVI, particularly in the presence of large inter-individual differences in blood pressure.
Pulse wave velocity, a common metric of arterial stiffness, is an established predictor for cardiovascular events and mortality. However, its intrinsic pressure-dependency complicates the discrimination of acute and chronic impacts of increased blood pressure on arterial stiffness. Cardio-ankle vascular index (CAVI) represented a significant step towards the development of a pressure-independent arterial stiffness metric. However, some potential limitations of CAVI might render this arterial stiffness metric less pressure-independent than originally thought. For this reason, we later introduced CAVI(0). Nevertheless, advantages of one approach over the other are left debated. This review aims to shed light on the pressure (in)dependency of both CAVI and CAVI(0). By critically reviewing results from studies reporting both CAVI and CAVI(0) and using simple analytical methods, we show that CAVI(0) may enhance the pressure-independent assessment of arterial stiffness, especially in the presence of large inter-individual differences in blood pressure.
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