4.2 Article

Immunohistochemical Comparative Study of Aggressive and Non-aggressive Central Giant Cell Lesions of the Jaws Based on the Tenascin-C Expression Profile

Journal

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
Volume 69, Issue 7, Pages 475-484

Publisher

SAGE PUBLICATIONS LTD
DOI: 10.1369/00221554211025479

Keywords

central giant cell lesions; histology; immunohistochemistry; monoclonal antibody; tenascin-C

Categories

Funding

  1. Technical Research Council of the Faculty of Dentistry, University of Antioquia [2020-27931]

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This study compared the immunohistochemical expression of Tn-C in CGCLs and found a significantly greater proportion of cases with moderate-to-intense staining of Tn-C in aggressive lesions. Analysis indicated a strong association between Tn-C expression and the aggressiveness of lesions.
The purpose of this study was to compare the immunohistochemical expression of tenascin-C (Tn-C) regarding clinicopathological variables and its association with the clinical behavior of central giant cell lesions (CGCLs). Forty-eight paraffin-embedded samples of CGCLs were selected. Based on clinical and radiographic features, the lesions were classified as aggressive (A-CGCLs) and non-aggressive (NA-CGCLs) subtypes. Histological assessment included the microvessel count (MVC), multinucleated giant cell (MGC) count, and the proportion of tissue area involved by mononuclear stromal cells/interstitial fibrosis. Immunoreactivity, immunolocalization, and distribution patterns of Tn-C were studied immunohistochemically. The association between Tn-C expression and clinicopathological characteristics was analyzed separately and adjusted for confounders using logistic regression models. A significantly greater proportion of cases with moderate-to-intense, intracellular, and diffuse staining of Tn-C was observed in A-CGCLs. CGCLs with a size >= 3.3 cm, fast growth, cortical disruption, high MVC/MGC counts, and low interstitial fibrosis showed a significantly greater frequency of moderate-to-intense, intracellular, and diffuse staining. Logistic regression analysis indicated a strong/independent association of these three immunohistochemical parameters with the aggressiveness of lesions. These data appear to suggest a possible role for Tn-C in the etiopathogenesis of CGCLs of the jaws, where its upregulation might favor the destructive behavior of A-CGCLs.

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