Journal
JOURNAL OF HEMATOLOGY & ONCOLOGY
Volume 14, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13045-021-01134-x
Keywords
Tumor microenvironment; B-cell lymphoma; Immunosuppression; Targeted therapy
Categories
Funding
- National Natural Science Foundation [81800194, 82070203, 81770210, 81473486, 81270598]
- Key Research and Development Program of Shandong Province [2018CXGC1213]
- Development Project of Youth Innovation Teams in Colleges and Universities of Shandong Province [2020KJL006]
- China Postdoctoral Science Foundation [2021T140422, 2020M672103]
- Technology Development Projects of Shandong Province [2017GSF18189]
- Translational Research Grant of NCRCH [2021WWB02, 2020ZKMB01]
- Shandong Provincial Natural Science Foundation [ZR2018BH011]
- Technology Development Project of Jinan City [201805065]
- Taishan Scholars Program of Shandong Province
- Shandong Provincial Engineering Research Center of Lymphoma
- Academic Promotion Programme of Shandong First Medical University [2019QL018, 2020RC006]
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B-cell lymphoma, a hematological malignancy with high clinical and biological heterogeneity, involves complex interactions between tumor cells and the tumor microenvironment. Exploring the tumor microenvironment provides new insights for cancer therapy.
B-cell lymphoma is a group of hematological malignancies with high clinical and biological heterogeneity. The pathogenesis of B-cell lymphoma involves a complex interaction between tumor cells and the tumor microenvironment (TME), which is composed of stromal cells and extracellular matrix. Although the roles of the TME have not been fully elucidated, accumulating evidence implies that TME is closely relevant to the origination, invasion and metastasis of B-cell lymphoma. Explorations of the TME provide distinctive insights for cancer therapy. Here, we epitomize the recent advances of TME in B-cell lymphoma and discuss its function in tumor progression and immune escape. In addition, the potential clinical value of targeting TME in B-cell lymphoma is highlighted, which is expected to pave the way for novel therapeutic strategies.
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