Journal
JOURNAL OF HAZARDOUS MATERIALS
Volume 417, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jhazmat.2021.126024
Keywords
Organophosphorus insecticide; Chiral; Enantioselective; Biodegradation; Cupriavidus nantongensis
Categories
Funding
- National Natural Science Foundation of China [31972314]
- Collaborative Innovation Projects of Anhui Province [GXXT-2019-034]
- High-level Talent Introduction Project of Anhui Agricultural University [rc522101]
- USDA [HAW5032-R]
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The study found that the strain Cupriavidus nantongensis X1(T) has enantioselective degradation characteristics towards the chiral organophosphorus insecticide isocarbophos, preferentially degrading the R isomer over the S isomer. S isomer only starts to degrade when the concentration ratio relative to R is greater than 62, and divalent metal cations can enhance the degradation ability of the strain.
The chiral pesticide enantiomers often show selective efficacy and non-target toxicity. In this study, the enantioselective degradation characteristics of the chiral organophosphorus insecticide isocarbophos (ICP) by Cupriavidus nantongensis X1(T) were investigated systematically. Strain X1(T) preferentially degraded the ICP R isomer (R-ICP) over the S isomer (S-ICP). The degradation rate constant of R-ICP was 42-fold greater than S-ICP, while the former is less bioactive against pest insects but more toxic to humans than the latter. The concentration ratio of S-ICP to R-ICP determines whether S-ICP can be degraded by strain X1(T). S-ICP started to degrade only when the ratio (CS-ICP/CR-ICP) was greater than 62. Divalent metal cations could improve the degradation ability of strain X1(T). The detected metabolites that were identified suggested a novel hydrolysis pathway, while the hydrolytic metabolites were less toxic to fish and green algae than those from P-O bond breakage. The crude enzyme degraded both R-ICP and S-ICP in a similar rate, indicating that enantioselective degradation was due to the transportation of strain X1(T). The strain X1(T) also enantioselectively degraded the chiral organophosphorus insecticides isofenphos-methyl and profenofos. The enantioselective degradation characteristics of strain X1(T) make it suitable for remediation of chiral organophosphorus insecticide contaminated soil and water.
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