Journal
JOURNAL OF HAZARDOUS MATERIALS
Volume 413, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jhazmat.2021.125467
Keywords
Chiral metal-organic frameworks; Post-modification; Cysteine enantiomer; Enantioselective sensors; Quartz crystal microbalance
Categories
Funding
- National Natural Science Foundation of China [21771158, 21775136, 21301149, 21401160]
- 333 Project of Jiangsu Province [BRA2019287]
- Six Top Talents Program of Jiangsu Province [2018-XCL-063, 2019-XCL-097]
- Qing Lan Project
- Yancheng Institute of Technology in Environmental Protection of Jiangsu Province [AE202101, AE202102]
- Key Laboratory for Advanced Technology in Environmental Protection of Jiangsu Province [AE202101, AE202102]
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In this study, a pair of UiO-MOF enantiomers (UiO-tart) were fabricated through post-modification, which can be further developed into enantiomeric sensors (UiO-tart@Au). These sensors displayed high enantioselectivity with a reported enantioselective factor of 5.97 +/- 0.54, the best performance reported so far.
the vital role of Cysteine (Cys) in biological processes and the hazardous effect of its D-enantiomer, discriminating Cys enantiomers without auxiliary enzyme is highly wanted. In this work, a pair of UiO-MOF enantiomers (UiO-tart) have been fabricated through post-modification, which could be further fabricated into enantiomeric sensing devices (UiO-tart@Au). By employing the Quartz Crystal Microbalance (QCM) technology, gravimetric discrimination of Cys enantiomers could be achieved. UiO-tart@Au is highly enantioselective, and the afforded enantioselective factor (5.97 +/- 0.54) represents the best performance reported ever. In the fabricated device, MOF layer acts as the chiral selector for specific Cys enantiomer, and the reaction between the captured Cys enantiomer and Au results in the mass growth of the system. Solid-phase extraction (SPE) gives an e.e. value of 71.6 +/- 3.8%, substantially confirming the chiral-selector role of UiO-tart. DFT calculations indicate that enantiomeric H-bonding effect and greater reaction enthalpy should be the reason. To the best of our knowledge, this work represents the first example of chiral tartaric acid derived MOF sensors for enantioselective discrimination of Cys, suggesting a promising potential of developing chiral MOFs based devices for enhanced enantioselective application.
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